PROTECTIVE ACTION OF KOPSININE F AGAINST EXPERIMENTAL LIVER INJURY IN MICE

Kopsinine F is an indole alkaloid. The present studies show that prior oral administration of kopsinine F 150 mg/kg significantly protected mice from liver injuries induced by intraperitoneal injection of CC1₄, thioacetamide and acetaminophen. The alkaloid also inhibited CCla induced lipid peroxidation (MDA, formation) of liver microsomes and ¹⁴CCl₄ covalent binding to lipids of liver microsomes in vitro. In addition, kopsinine F significalty induced hepatic mierosomal cytochrome P-450 in mice. The results indicate that kopsinine F has hpatoeprotective activity in mice.