ANALYSIS OF POPULATION PHAKMACOKINETICS WITH NONMEM IN CLINICAL PATIENTS TREATED WITH AMIKACIN BY INTRAVEN0US INFUSION

CIinical data(n=275)collected from 52 patients with respiratory tract infectionreceiving amikacin(AMK)by intravenous infusion were analysed with NONMEM,a computerprogram designed for estimating population phannacokinetic parameters.COncentrations of AMK inserum were detennined by fluorescence polarization immunoassay(FPIA).A two compartment openmodel was used for analysing AMK population phannacokinetics.The influence of bedy weight(BW),creatinine clearance(CC),administration history(HIS)and state of pathology(chronicobstructional pulmonary diSease,COPD)on pharmacokinetics was investigated.The pharn1acokinetic parameters of AMK were shown to be influenced by creatinine clearance(CC)and COPD.