Zhang Xiuping, Shen Defu , Zhang Xiuju Chen Lin, Dai Zurui , Shu Kangquan, . STUDIES ON ANTIMALARIALS Ⅵ. SYNTHESIS AND ANTIMALARIAL ACTIVITIES OF SOME 2,4-DIAMINO-6-SUBSTITUTED AMINO SULFONYL QUINAZOLINE DERIVATIVESJ. Acta Pharmaceutica Sinica, 1981, 16(11): 877-880.
Citation: Zhang Xiuping, Shen Defu , Zhang Xiuju Chen Lin, Dai Zurui , Shu Kangquan, . STUDIES ON ANTIMALARIALS Ⅵ. SYNTHESIS AND ANTIMALARIAL ACTIVITIES OF SOME 2,4-DIAMINO-6-SUBSTITUTED AMINO SULFONYL QUINAZOLINE DERIVATIVESJ. Acta Pharmaceutica Sinica, 1981, 16(11): 877-880.
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STUDIES ON ANTIMALARIALS Ⅵ. SYNTHESIS AND ANTIMALARIAL ACTIVITIES OF SOME 2,4-DIAMINO-6-SUBSTITUTED AMINO SULFONYL QUINAZOLINE DERIVATIVES

    Abstract
  • In the present communication sixteen derivatives of 2, 4-diamino-6-substitutedaminosulfonylquinazolines were synthesized as potential antimalarial agents.Screening tests for therapeutic effect on mice infected with Plasmodium berghei and for prophylactic effect on mice infected with P. yoelii sporozoites,.showed that 2,4-diamino-6-(piperidyl-1) sulfonyl quinazoline acetate (Ⅲ) at daily oral dose of 0.31 mg/kg for 3 consecutive days possess pronounced causal prophylactic activity against P. yoelii.
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