STUDIES ON URANIUM MOBILIZATION AGENTS VI: SYNTHESIS OF 2,3-DIHYDROXY-4-CARBOMETHOXYBENZYL AMINOCARBOXYLIC ACID AMIDES CHELATING AGENTS

In searching for new chelation therapy drugs against uranium intoxication, a series of N-carboxymethyl-N- (substituted carbamoylmethyl)- 2, 3- dihydroxy- 4- carbomethoxybenzylamine was synthesized starting with o-vanillin. The effect on detoxieation of UO₂ (NO₃)₂, CuSO₄ and NiCl₂ in mice was tested. Some of them (IVa, IVd, IVf and IVg) were shown to be good antidotes for acute uranium intoxication, but all were less effective for Cu²⁺ and Ni²⁺.