SOME BIOLOGICAL CHARACTERISTICS OF SIMIAN MALARIA MODEL OF PLASMODIUM CYNOMOLGI——ANOPHELES STEPHENSI SYSTEM AND ITS RESPONSES TO CURRENT ANTIMALARIALS

Under certain conditions the infection rate of the Anopheles stephensi to Plasmodium cynomolgi was 77±0.15%. The rhesus monkeys were fairly susceptible to the parasite infection. All monkeys were infected after being inoculated intravenously with more than 10⁵ sporozoites each. Test of current antimalarial drugs in this model showed that primaquine and pyrimethamine exhibited Causal prophylactic activity. Primaquine (2.5 mg (base)/kg×5 days) used in combination with chloroquine (20 mg (base)/kg×3 days) showed radical curative effect, while chloroquine exhibited only suppressive activity when used alone (20 mg(base)/kg×3 days).