APPLICATION OF SIGNAL MULTIPLIER DERIVATIVE SPECTROPHOTOMETRY AND EQUIVALENT DERIVATE DERIVATIVE SPECTROPHOTOMETRY TO THE DETERMINATION OF PROMETHAZINE AND PARACETAMOL IN XIRETONG INJECTION

This paper provides the basic principle and experimental technique of signal multiplier derivative and equivalent derivate derivative spectrophotometry. Quantitative analysis of four component-mixture can be done without separation. This method was investigated to assay the contents of promethazine HCl and paracetamol in Xiretong injection by using UV-210A spectrophotometer and its attachment (DES-2). The average recoveries of promethazine HCI and paracetamol were 90.09±0.53%(CV) an 90.84±0.91%(CV) respectively, The results obtained are satisfactory both in precision and in accuracy.