UPLC-Q-TOF/MS analysis of naringin and naringenin and its metabolites in rat urine and feces after intragastric administration of alcohol extract of Exocarpium Citri Grandis

To analyze naringin, naringenin and its metabolites in rat urine and feces after intragastric    administration of alcohol extract of Exocarpium Citri Grandis, healthy SD rats were fed with alcohol extract   of Exocarpium Citri Grandis for 3 days.  On the last day, 0−24 h feces and 0−4 h, 4−8 h, 8−24 h urine were  collected and analyzed by UPLC-Q-TOF/MS.  The post-acquisition data were processed using Metabolynx^TM.  The result is that naringin and its 6 metabolites, naringenin and its 4 metabolites were detected in the urine of rat.  Meanwhile, naringin and its 3 metabolites, naringenin and its 2 metabolites were detected in the feces of rat.