STUDIES ON SOME PHYSICAL CHARACTERISTICS OF CYCLOSPORINE A (CyA) SOLID DISPERSIONS

In this paper, poloxamer and PVP were used as carriers. CyA-poloxamer and CyA-PVP solid dispersions were prepared using the melting-solvent method or solvent method, respectively. The percentage compositions of the solid dispersions ranged from 10∶90 to 90∶10. Hot stage microscopy, powder X-ray diffraction and differential scanning calorimetry were used to examine the physical-chemical characteristics of the solid dispersions to provide some reliable and scientific basis for preformulation of CyA.