Design and synthesis of quinoxaline derivatives and their antitumor activities

AimTo design and synthesize novel quinoxaline derivatives as antitumor agents. MethodsUsing 4-chloro-2-nitroaniline as a starting compound, followed by substitution, reductive cyclization, oxidation, and chlorination, to give the key intermediate 2,7-dichloroquinoxaline (7), which reacted with different phenolic compounds to afford quinoxaline derivatives. ResultsThe structures of the target molecules were characterized by elemental analysis, ¹H NMR, MS, and IR. ConclusionAt concentration of 1×10^-4 mol·L^-1, some of the derivatives showed equal antitumor activities to XK469.