Studies on chiral inversion of dextropantoprazole in human

AimTo study the chiral inversion of dextropantoprazole in human. MethodsThree healthy Chinese male volunteers after an oral dose of 40 mg dextropantoprazole. An HPLC method was developed and used to determine the total plasma concentrations of each enantiomer. The ratios of the enantiomers in plasma samples were measured on a Chiral-AGP column. The plasma concentration of each enantiomer was then calculated using the ratios of enantiomers and total concentrations of the two enantiomers previously measured. ResultsThe AUC0-t of levopantoprazole was only 1.5% of the total AUC0-t of enantiomers. ConclusionThe chiral inversion from dextropantoprazole to levopantoprazole does not occur in the three healthy Chinese male volunteers after an oral dose of 40 mg dextropantoprazol.