ISOLATION AND DENTIFTCATION OF ISOANGELOL, ANPUBESOL AND OTHER COUMARINS FROM ANGELICA PUBESCENS MAXIM

Nine coumarins were isolated from dichloromethane extract of the roots of Angelica pubescens Maxim. Seven of them were identified as osthol (Ⅰ), columbianetin acetate (Ⅱ), columbianetin (Ⅲ), bergapten (Ⅳ), angelol (Ⅴ),xanthotoxin (Ⅵ) and isoimperatorin (Ⅶ). (Ⅵ) and (Ⅶ) were isolated for the first time from this plant. Two new coumarins were elucidated as isoangelol (Ⅷ), a geometric isomer of angelol C₂₀H₂₄O₇ α_D²⁰-133.5 and anpubesol C₂₀H₂₆O₇ α_D²⁰ -72.5 on the basis of spectral evidences.