In vitro and in vivo anti-influenza virus activity of ribavirin injection

Ribavirin is a broad-spectrum inhibitor against several unrelated DNA or RNA viruses in vitro and in vivo.  In this paper the in vitro and in vivo study of anti-influenza virus activity of ribavirin (RBV) injection had been reported.  The in vitro antiviral activity of ribavirin injection against influenza virus A and B was  studied by CPE.  The in vivo protective action of ribavirin injection against influenza A/FM/1/47(H1N1) mouse adapted strain infected mouse was studied with mouse model.  The results showed ribavirin injection has strong inhibitory activity against 7 virus strains tested in vitro.  Ribavirin injection could significantly increase virus infected mouse survival rate and survival days and improve lung pathogen and lung index.