Synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol

Aim To study the synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol. Methods Pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol were synthesized primarily from 2-methyl-5-nitroimidazol, norfloxacin, ciprofloxacin, enoxacin via nucleophilic substitution and esterification. The antibacterial activity of the nine target compounds were tested. Results Nine new compounds were synthesized (IIa～c and IIIa～f). The structure of the title compounds were identified by ¹HNMR, MS as well as elementary analysis. Conclusion Compounds IIa, IIb and IIc showed antibacterial activity, and were worth further studying.