SYNTHESIS OF 1,4-DIHYDROPYRIDINES WITH BLOOD PRESSURE AND BLOOD-FAT LOWERING EFFECTS

To develop new drugs with the effects of lowering blood-fat and blood pressure, compounds 1～7 and 10 were synthesized by the reactions of 2-methyl-2-4-(4-chlorobenzoyl)phenoxypropionyl chloride with a hydroxyl group in 1,4dihydropyridines. Compounds 8 and 9 were obtained by the reactions of 2-methyl-2-4-(4- chlorobenzoyl)phenoxypropionyl chloride with salicylic aldehyde first, and then with β-aminocrotonates. All 1～10 are new compounds, and their structures were elucidated by means of ¹HNMR and MS. The effects of compounds 1～10 on lowering cholesterol, triglyceride and blood pressure were investigated, and some of which were found to have the effects of lowering triglyceride and blood pressure.