PHARMACOKINETICS AND PHARMACODYNAMICS OF MATRINE AND OXYMATRINE

On measuring the percentage of QTc interval prolongation, the pharmacokineticand pharmacodynamic profiles of iv matrine or oxymatrine in rabbits were analyzed by combined phar-macokinetic and pharmacodynamic model. The plasma concentration-time profiles of the two drugscan be described by a two-compartment open model, and the relationship between effect and effectcompartment concentration of both drugs can be represented by the sigmoid E_max model. Marked differ-ences in pharmacokinetic and pharmacodynanic parameters between the two drugs were found, buttheir pharmacokinetic and pharmacodynamic properties were dose-independent in the dose ranges usedin the experiment.