DISSOLUTION RATE OF ACICLOVIR SOLID DISPERSION AND ITS RELATIVE BIOAVAILABILITY IN HUMAN

AIM: To evaluate the bioavailability of aciclovir (ACV) capsule prepared by the method of solid dispersion. METHODS: A single oral dose of aciclovir capsule or tablet was administrated to HBsAg positive patients randomly and their serum aciclovir concentrations were determined by HPLC. The dissolution rates of capsule and tablet were investigated by in vitro method. RESULTS: The areas under curve (AUC) of aciclovir capsules and tablets were 6271.33 h.ng.mL^-1 and 4101.00 h.ng.mL^-1, respectively. The cumulative release of aciclovir capsule was significantly higher (84.63%) than that of tablets (2.08%) within 30 minutes. CONCLUSION: The bioavailability and dissolution of rates of aciclovir capsule made with the method of solid dispersion method were higher than those of aciclovir tablet.