STUDIES ON URANIUM MOBILIZATION AGENTS. Ⅲ. SYNTHESIS OF 2, 3-DIHYDROXY-5-CARBOALKYLOXYBENZYL AMINOCARBOXYLIC ACID AMIDES CHELATING AGENTS

In searching for new chelation therapy drugs against uranium intoxication, a series of N-carboxymethyl-N-(substituted carbamoylmethyl)-2, 3-dihydroxy-5-carboalkyloxybenzylamine was synthesized starting with 2, 3-dihydroxy-5-carboalkyloxybenzylamine diacetic acid. The effect on the elimination of uranium salts from animal bodies was tested. Four of them (Ⅳ_n, Ⅳ_q, Ⅳ_u and Ⅳ_v) were shown to be more effective than tiron or phosphicine in accelerating uranium excretion in rats.