EFFECT OF THYKOTROPIN-RELEASING HORMONE ANALOGUE(YM14073) ON EXPERIMENTAL BRAIN CONTUSION AND EDEMA IN RATS

The effect of TRH analogne,YM 14673:N^α-(S)-4-oxo-2-azetidinyl-earbenyl)-L-histidyl-L-prolinamide dihydrate,on traumatic brain edema were studied in maleWistar rats,The cerebral contusion was produced by Feeney's dropping weight methed. Animals wererandomly divided into 4 groups:normal group and YM14673(0.1 mg·kg^-1,ip), YM14673(1.0 mg·kg^-1,ip)and a control group(given equal volume of physiological saline,ip)after cerebralcoutusion. Contents of water in brain tissue were measured.These results suggest that treatments withYM14673 significantly reduced brain edema than control group(P<0.05).