Synthesis and anti-inflammatory activity of n-(4-arylamidophenyl)methanesulfonamide derivatives

AimTo study the anti-inflammatory activity of n-(4-arylamidophenyl)methanesulfonamide derivatives. MethodsThe target compounds were synthesized from P-nitroaniline via three steps and were evaluated for anti-inflammatory activity with the model of xylene-induced ear edema in mice. ResultsEleven compounds were obtained and confirmed by IR, ¹HNMR and MS. Some compounds were shown to have significant anti-inflammatory activity. Conclusionn-(4-arylamidophenyl)methanesulfonamide showed appreciable anti-inflammatory activity.