HUO Lian-Chao, ZHANG Yu-Liang, LEI Lei, LIU Shuai-Nan, SHEN Zhu-Fang, WANG Yu-Ling, SONG Hong-Rui, FENG Zhi-Jiang. Salicylic acid derivatives as simplified and novel GK small molecule activatorsJ. 药学学报, 2013,48(4): 514-520.
Citation: HUO Lian-Chao, ZHANG Yu-Liang, LEI Lei, LIU Shuai-Nan, SHEN Zhu-Fang, WANG Yu-Ling, SONG Hong-Rui, FENG Zhi-Jiang. Salicylic acid derivatives as simplified and novel GK small molecule activatorsJ. 药学学报, 2013,48(4): 514-520.
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Salicylic acid derivatives as simplified and novel GK small molecule activators

    Abstract

  • Glucokinase (GK) is a new target for the treatment of type Ⅱ diabetes mellitus (T2DM).  In order to find a structure-simplified small molecule GK activator, 19 salicylic acid derivatives were designed and synthesized based on new lead compound (1).  Experimental results showed that the potency of compound 8h is superior to control RO-28-0450 in GK activation.

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