COMBINED PHARMACOKINETIC—PHARMACODYNAMIC MODEL ANALYSIS OF N-ACETYL PROCAINAMIDS FOLLOWING INTRAVENOUS INFUSION IN RABBITS

The pharmacokinetic and pharmacodynamic profiles of N-acetyl procainamide were analyzed by integrated PK-PD model following intravenous infusion to rabbits. No significant differences between the PK parameters estimated from iv administration and intravenous infusion were found. However, two of the PD parameters were shown to be significantly different. The values of E_max, K_eo, S, EC₅₀ were found to be 120±13.2 ms, 0.0182±0.007 min^-1, 2.26±0.93, 6.31±0.71 μg/ml respectively following intravenous infusion; the corresponding values following iv administration were 53.6 ± 2.5 ms, 0.061±0.017min^-1, 2.19±0.39, 6.21±1.74 μg/ml respectively.