STUDIES ON THE ANTIMONIALS FOR SCHISTOSOMIASIS Ⅰ. WATER SOLUBLE ORGANIC TRIVALENT ANTIMONY COMPOUNDS.

Four water soluble organic trivalent antimony compounds such as sodium antimony gluconate, potassium antimony saccharate, sodium antimony citrate and sodium antimony mannitol have been prepared by the reaction of polyhydroxyl acids or polyhydroxyl alcohols with antimony trichloride, antimonyoxychloride or antimonous oxide in the presence of alkali. The aqueous solution of sodium antimony gluconate is not stable and can be stablized by adjusting its pH value with the addition of gluconic acid. The sodium antimony mannitol, prepared from 2 moles of mannitol and 1 mole of antimonous oxide, is also not stable. Its stability can be increased by changing the mole ratio of the reactants, mannitol and antimonous oxide, to 3:1. This product is probably a complex compound of sodium antimony mannitol and mannitol. All of them have been proved to possess the therapeutic action in the treatment of experimental infections of Schistosoma japonicum in mice.