CHEMOTHERAPEUTIC STUDIES ON SCHISTOSOMIASIS ⅩⅩⅩⅣ. THE SYNTHESIS OF DERIVATIVES OF α-CHLOROβ-(5-NITRO-2-FURYL) ACRYLAMIDES AND α-CHLORO-β-( 5-NITRO-2-FURYL ) VINYL/OXADIA ZOLES

Synthesis of 35 new compounds of α-chloro-β-(5-nitro-2-furyl) acrylamides and 5-α-chloro-β-(5-nitro-2-furyl ) vinyl-oxadiazoles by known methods are reported. In preliminary test in mice 10 compounds were found to possess pronounced activity against Schistosomiasis japonica. Among these Ⅰ₁₂, Ⅰ₁₃, Ⅰ₁₄, Ⅰ₂₀, Ⅱ₁ and Ⅱ₈ were shown to be the most effective.