HU Ai-xi, CAO Sheng-chunCHENG Ya-ping, CHEN Long, DONG Xian-ming, . ONE-POT SYNTHESIS OF dl-NAPROXEN BY REARRANGEMENTJ. Acta Pharmaceutica Sinica, 2000, 35(11): 818-820.
Citation: HU Ai-xi, CAO Sheng-chunCHENG Ya-ping, CHEN Long, DONG Xian-ming, . ONE-POT SYNTHESIS OF dl-NAPROXEN BY REARRANGEMENTJ. Acta Pharmaceutica Sinica, 2000, 35(11): 818-820.
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ONE-POT SYNTHESIS OF dl-NAPROXEN BY REARRANGEMENT

    Abstract
  • AIM　To synthesize dl-naproxen by rearrangement method. METHODS　dl-Naproxen was synthesized by halogenation, ketalization, rearrangement and hydrolysis, using cupric halide as halogenation agent. RESULTS　Total yields were 74.0%～92.6% based on 6-methoxy-2-propionyl naphthalene. CONCLUSION　Total yield was higher by one-pot rearrangement approach.
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