Yang Yushe, Ji Ruyun, Chen Kaixian , Ding Jian, . STUDIES ON SYNTHESIS ANTIBACTERIAL AND ANTITUMOR ACTIVITY OF (S)-(-)-OFLOXACIN ANALOGUESJ. Acta Pharmaceutica Sinica, 1999, 34(2): 119-124.
Citation: Yang Yushe, Ji Ruyun, Chen Kaixian , Ding Jian, . STUDIES ON SYNTHESIS ANTIBACTERIAL AND ANTITUMOR ACTIVITY OF (S)-(-)-OFLOXACIN ANALOGUESJ. Acta Pharmaceutica Sinica, 1999, 34(2): 119-124.
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STUDIES ON SYNTHESIS ANTIBACTERIAL AND ANTITUMOR ACTIVITY OF (S)-(-)-OFLOXACIN ANALOGUES

    Abstract
  • AIM: To design and prepare quinolone compounds with antibacterial and antitumor activities. METHODS AND RESULTS: According to rational drug design principle, a series of novel analogues of (S)-(-)-ofloxacin has been prepared and the influences on structure-activity relationships was also discussed. CONCLUSION: Their in vitro antitumor and antibacterial activities were evaluated. The results showed that compound 16～20 have good antitumor and antibacterial activities.
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