Chang Junbiao, Xie JingxiChen Rongfeng , Liu Peng, . TOTAL SYNTHESIS OF (±) DEOXYSCHISANDRIN AND ITS ANALOGUESJ. Acta Pharmaceutica Sinica, 1999, 34(12): 913-917.
Citation: Chang Junbiao, Xie JingxiChen Rongfeng , Liu Peng, . TOTAL SYNTHESIS OF (±) DEOXYSCHISANDRIN AND ITS ANALOGUESJ. Acta Pharmaceutica Sinica, 1999, 34(12): 913-917.
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TOTAL SYNTHESIS OF (±) DEOXYSCHISANDRIN AND ITS ANALOGUES

    Abstract
  • AIM: To synthesize (±) deoxyschisandrin and its analogues. METHODS: The compounds are readily prepared by intramolecular oxidative coupling with 2,3 dichloro 5,6 dicyano 1,4 benzoquinone (DDQ) in trifluoroacetic acid (TFA). The structures of these compounds are confirmed by MS, 1HNMR and EA. RESULTS: Twenty one compounds have been synthesized among them 10 (5, 6, 8, 9, 11, 12, 14, 15, 17 and 20) are new compounds. CONCLUSION: The results of preliminary pharmacological tests on compounds have showen that compounds 10～15 have anti inflammation activities and compounds 19～21 have anti convulsive activities.
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