IN VITRO INHIBITIVE ACTIVITY OF PHOSPHONOTRIPEPTIDES TOWARD ANGIOTENSIN- CONVEKTING ENZYME AND STUDY ON STRUCTURE-ACTIVITY RELATIONSHIP

A series of phosphonotripeptides were synthesized according to structure-basedrational drug design. The in vitro inhibitive activi ties of these compounds toward angiotensin-converting enzyme were detennined.The in vitro activities of some of these compounds were shownto be comparable with that of Captopril.Furthennore,the structure.activity relationship(SAR)ofthese compounds was discussed.