The action of p38 MAP kinase and its inhibitors on endometriosis

Endometriosis, an oestrogen-dependent disorder, is related to inflammation.  p38 Mitogen    activated protein kinases (p38 MAPK) can be activated by sex hormone and inflammatory factors, which plays an important role in many cellular reactions such as apoptosis, proliferation, inflammation and stresses, etc.  Many studies showed that p38 MAPK was participated directly in regulating the pathogenesis of endometriosis.  The special regulatory action of p38 MAPK on sex hormone and inflammation may help us to understand the  intricate endometriosis pathological hypothesis.  p38 MAPK inhibitors play a key role in the the study of    endometriosis, and show great promise for the future.  Blocking and regulating the expression of p38 MAPK on the signal transduction pathway level may hope to be a new strategy to prevent and treat endometriosis.