A new indole derivative from endophyte Myrothecium roridum IFB-E091 in Artemisia annua

Three compounds were isolated from solid culture of endophyte Myrothecium roridum IFB-E091 in Artemisia annua. Their structures were determined as (S)-(-)-N-2-(3-hydroxy-2-oxo-2,3-dihydro-1H-indol- 3-yl)-ethyl-acetamide (1), N-(4-hydroxyphenethyl)acetamide (2) and asperfumoid (3), in which compound 1 was a new indole derivative. In cytotoxicity assay, the compound 1 had no obvious inhibition activity in human hepatoma cell line SMMC-7721 and human cervical carcinoma cell line HeLa.