PHARMACOKINETICS OF ZINC ACEXAMATE(ZAC)IN RATS

Zinc acexamate(ZAC)is a new antiulcer drug.This paper reports the pharma-cokinetics of ZAC in rats after single oral administration.The concentrations in biological sampleswere detected by spectrophotometry.This study shows that the concentration-time curve of ZAC inblood conformed to a single-compartment open model after 250,500 and 750 ng·kg^-1 ig.ZACabsorption was fast and the peak plasma level appeared in 1.5h.The C_max,AUC and CL/F wereshown to be dose dependent.Two hours after oral administration of ZAC to nomal rats,the highestlevel of ZAC was present in the gastrointestinal tract,while appreciable ZAC was present in thekidney,liver,plasma and lung.The level of ZAC in heart,spleen and brain Was lower,no drug wasdetected in muscles and uterus.Six hours after oral administration,the drug concentration in varioustissues decreased rapidly,but that of the gastrointestinal decreased very slowly.Feces excretion was animportent route of excretion.ZAC excretion was about 11.7% of the administered dosage in feceswithin 48 h period,and the excreted amount from urine and bile was very small.