TUMOUR CHEMOTHERAPY ⅩⅢ.SOME SCHIFF'S BASES CONTAINING THE NITROGEN MUSTARD GROUPING

In part Ⅰ the authors have prepared 1-p-nitrophenyl-2-p-bis(2-chloroethyl)amino benzylidene-amino-1, 3-propandiol (Ia) by condensing 1-p-nitrophenyl-2-amino-1, 3-propandiol with p-bis(2-chloroethyl)aminobenzaldehyde. Pharmacological examination revealed that Ia had marked inhibitory effect on sarcoma M-57, Jensen Sarcoma in rats and Sarcoma 180 in mice. In this investigation, other Schiff's bases were prepared by condensing some physiologically active amines with aromatic aldehydes containing the N, N'-bis(2-chloroethyl) amino grouping. Their melting points and solvents of crystallization are listed in Tables 1, 2, and, 3. Among these conpounds it was found that the Schiff's base of o-aminophenol (Ⅳ) had a marked inhibitory action on Jensen sarcoma in rats.