SYNTHESIS AND ANTIFUNGAL ACTIVITIES OF 1-2- (SUBSTITUTED-PHENYL)METHOXY-2-(SUDSTITUTED-PHENYL) ETHYL-1H-TRIAZOLES AND BENZTRIAZOLES

Thirty-nine1-｛2-(2,4-dichlorophenyl )methoxy-2-(substituted-phenyl)ethyl｝-1H-triazoles and benztriazoles were svnthesized and all title compounds are reported for the first time.Results of preliminary biological tests showed that the most active compounds 6 and 13 are 4～10times more active than the lead compound econazole.The antifungal activities of compounds 10 ,12,14,15,20,22,23,28,30 and 31 are better than or comparable to the activities of econazole andclotrimazole against most fungi.Compounds 23 and 31 are 30 times more active than econazole andclotrimazole against Fonseaea pedrosoi.Compound 22 is 4 and 8 times more active than clotrimazole andeconazole, respectively,against Candide albicans.