In vitro antitumor activity and synthesis of the key intermediate of bakuchiol

The in vitro antitumor activity of bakuchiol was exploited, compared with tamoxifen.  The    result of biological activities showed that bakuchiol could inhibit human breast cancer and the IC₅₀ values were 2.89×10⁻⁵ mol·L⁻¹ and 8.29×10⁻³ mol·L⁻¹ against the cells line T-47D and MDA-MB-231 respectively.  On   the other hand, the key intermediate to synthesize bakuchiol was obtained by the method of Ireland-Claisen   rearrangement.  Comparing with traditional Claisen rearrangement, the reaction conditions are milder and the reaction reagents are safer.