SYNTHESIS OF N-(4-CARBOMETHOXY-4-PHTHALIMIDOBUTANOYL)-N-SUBSTITUTED GLYCINES，PROLINE AND PYROGLUTAMIC ACID

This paper reports the synthesis of eleven N-(4-carbomethoxy-4-phthalimidobu-tanoyl)-N-substituted glycines(VⅡ_1～9)，proline(VⅡ₁₀)and pyroglutamic acid(VⅡ₁₁)expected tohave inhiMtory activity on angiotensin converting enzyme．All of the compounds mentioned above and the corresponding t-butyl esters of VⅡ_1～9 were not reported in the literature previously．The structures were confirmed through their IR，¹HNMR，MS spectra and elemental analysis．In preliminary test in rats,compounds VII₈，VII₉ and VII₁₀ showed marked hypotensive activity．