STUDIES ON THE ALKALOIDS OF AMARYLLIDACEAE——Ⅲ.THE ALKALOIDS OF LYCORIS SQUAMIGERA MAXIM.AND OTHER TWO LYCORIS SPECIES,AND A NEW ALKALOID,SQUAMIGERINE
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Abstract
Nineteen crystalline alkaloids have been isolated from the bulbs of Lycoris squamigera Maxim. Twelve of them have been proved to be identical with lycorine, pseudolycorine, lycorenine, homolycorine, tazettine, norpluviine, galanthamine, epigalanthamine, vittatine, pluviine, lycoramine, hippeastrine, respectively. One of them has been proved to be a new alkaloid, and named squamigerine. The new alkaloid, squamigerine, C18H21O5N, m. p. 260℃, αD34 165° (CHCl3), contained one methylenedioxy, methoxy, N-methyl, hydroxy group and one double bond. Its molecular formula and functional groups were identical with those of tazettine, but its m. p., αD and Rf were different from those of the latter. To confirm if squamigerine is the stereoisomer of tazettine, we compared the ultraviolet and infrared absorbtion spectra of them, and found that they resembled each other very closely. Because squamigerine is also apparently not identical to epitazettine, it was deduced to be the stereoisomer of tazettine, in which the B/D or C/D ring system was different from that of tazettine. Besides, seven crystalline alkaloids have been isolated from L. radiata Herb., and proved to be identical with Iycorine, pseudolycorine, homolycorine, tazettine, galanthamine, lycoramine and lycorenine respectively. The same seven alkaloids have also been isolated from L. aurea Herb.
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