DERIVATIVES OF 6-AMINOPENICILLANIC ACID Ⅰ. SYNTHESIS OF 6-(SUBSTITUTED ACRYLAMIDO) PENICILLANIC ACID

Twenty-two new derivatives of 6-aminopenicillanic acid have been prepared either by the mixed carboxylic-carbonic anhydride or by the usual acyl chloride method. They were isolated and purified either as their N-ethylpiperidine or as their N, N'-dibenzyl- ethylenediamine salts. Biological evaluations of these derivatives are in progress.