A new triucallane derivative from Salacia hainanensis Chun et How

Chemical constituents of the roots and stem of Salacia hainanensis Chun et How were isolated and purified with column chromatography on silica gel, Sephadex LH-20 and preparative HPLC.  Their structures were elucidated based on physicochemical and spectral spectroscopic analysis.  Depending on the activities of anti-α-glucosidase and inhibiting AGEs (advanced glycation end products, AGEs) formation in vitro, nine   compounds were identified as 26, 27-dihydroxy-7, 24-tirucalladien-3-one (1), abruslactone A (2), lupeol (3),  21α, 30-dihydroxy-D: A-friedooleanan-3-one (4), 15α-hydroxyfriedelan-3-one (5), friedelin (6), mangiferin (7), epicatechin (8) and β-sitosterol (9), separately.  Among them, compound 1 is a new compound, and compound   2 was isolated from the Salacia genus for the first time, while, compounds 3, 4, 5, 8 were obtained from this plant for the first time.