Preparation of gelatin nanogel modified with fluoride anion and its ultrasonic triggered release characteristics

AimTo investigate the preparation, shape and ultrasound triggered release characteristics of gelatin nanogel modified with fluoride anion. MethodsAdriamycin gelatin nanogel modified with fluoride anion (ADM-FMNG) was prepared by co-precipitation with fluoride anion. The content and encapsulation rate of adriamycin were measured by HPLC method. The size and shape of ADM-FMNG were determined by electron microscope. The size and distribution of ADM-FDNG before and after sonication were measured by laser size analysis device. ResultsThe average diameter of ADM-FMNG was (46±12) nm. Adriamycin encapsulated rate and loading were 87.2% and 0.091 g·L^-1, respectively. 48.5% of adriamycin was released within 50 h while in vitro at 37 ℃. Under the action of ultrasound that has the frequency of 20 kHz, 0.4 W·cm^-2 of power density and 7-8 min duration, 51.5% of adriamycin in ADM-FMNG was released that was significantly higher than control group, the size of ADM-FMNG was changed from (46±12) nm to (1 212±35) nm and restored after ultrasound stopped for 3-4 min. ConclusionADM-FDNG system has the sensitive ultrasound triggered release characteristics.