SYNTHESIS OF N-(2-CARBOMETHOXYPHENYLOXY/THIO A CETYL)-N-SUBSTITUTED GLYCINES

Thirteen N-(2-carbomethoxyphenyl oxy/thio acetyl)-N-substituted glycines (VI _1-7 and XI_1-6) expected to have inhibitory activity on angiotensin-converting enzyme were synthesized.All of the title compounds and thirteen corresponding t-butyl esters(V_1-7 and X_1-6) were not found in literature.In preliminary test,the inhibitory activity activity of compound XI₅ on ACE in vitro was 70% that of captoprill.