Synthesis and antiviral activities of geldanamycin analog TC-GM in vitro

In order to find antiviral compounds with novel structures, geldanamycin and lamivudine with different antiviral mechanisms were conjunctively synthesized to acquire a new compound TC-GM, and the antiviral activity of TC-GM was measured.  The antiviral activity against HIV-1 was examined by p24 antigen ELISA kit.  The activity against HBV was examined by dotblot.  The activity against HSV and CoxB virus was examined by CPE.  TC-GM exhibited broad-spectrum antiviral activities similarly like geldanamycin.  TC-GM inhibited the replication of different viruses, including HIV-1, HBV, HSV 1 and 2, CoxB6.  TC-GM showed more potent inhibitory activity against HIV-1 and HBV than other detected virus.