Effects of matrine, oxymatrine and resveratrol on HERG channel expression

Because HERG potassium channel has important effects on both proarrhythmia and anti-arrhythmia, we use immunofluorescence and Western blotting methods to detect the expression of HERG channel of HERG-HEK cells in different concentrations of matrine, oxymatrine and resveratrol. The findings showed that both matrine (1 μmol·L^-1) and oxymatrine (1 μmol·L^-1) increased HERG channel expression (n=5, P<0.05), while matrine (100 μmol·L^-1) decreased HERG channel expression (n=5, P<0.05), resveratrol didn’t affect HERG channel expression. In conclusion, different concentrations of matrine and oxymatrine affect HERG channel expression, while there is no relationship between resveratrol and HERG channel expression. It provides a theoretical support for the safety and mechanism of anti-arrhythmic drugs.