EFFECTS OF TAURINE AND ENALAPRIL ON BLOOD PRESSURE, PLATELET AGGREGATION AND THE REGRESSION OF LEFT VENTRICULAR HYPERTROPHY IN TWO-KIDNEY-ONE- CLIP RENOVASCULAR HYPERTENSIVE RATS

In two-kidney-one-clip(2k-1c)renovascular hypertensive rats ,the bloodpressure,left ventricular weight/body weight( LVW/BW)ratio and blood platelet aggregation wereincreased significantiy.Enalapril(Ena) 6 mg·kg^-1 ·d^-1ig 9wk and Taurine 30 mg· kg^-1· d^-1 ig9wk can not only decrease the high blood pressure,LVW/BW ratio, but also the blood plateletaggregation induced by ADP or thrombin,though still different from that of the normal group.Whenthe 2k-1c renovascular hypertensive rats were treated with both Ena and Tau,the blood pressure andblood platelet aggregation were decreased to the same as that of the normal group, and the LVW/BWratio was also lowered markedly ,though still higherthan that of the normal group.These results show that both Ena and Tau can reverse the left ventricular hypertrophy,decreasethe blood pressure and suppress the blood platelet aggregation in 2k-1c renovascular hypertensive rats.When treated with both drugs ,the effects can be improved.It suggests that the two drugs can enhancethe effects when used together, and that they may be two good agents for treatment of hypertension.