ASYMMETRIC SYNTHESIS OF NAPROXEN，AN ANTIINFLAMMATERY ANALGESIC

AIM: To systhesize naproxen by asymmetric method. METHODS: Naproxen was systhesized by acetalization, asymmetric bromination, hydrolysis, rearrangement and catalytic tranfer hydrogenolysis from 6-methoxy-2-propionyl naphthalene, using (2R,3R)-dimethyltartrate as chiral auxiliary, Br₂ as brominating agent, KH₂PO₄ as rearrangement agent, 10% Pd-C/HCO2NH4 as catalytic transfer hydrogenolytic agent. RESULTS: Total yield was 54%, e.e. value of product was 94%. CONCLUSION: The higher chemical yield and optical yield were obtained.