STUDIES ON CDDP-ALBUMIN MICROSPHERES FOR HEPATIC APTERIAL CHEMOEMBOLIZATION

An optimum procedure was established by orthogonal test for preparing cis -platin albumin microspheres(CDDP- AMS ) with emulsion-heating stabilization method. The factors which affect particle size and release rate in vitro were studied. The particle size focusing on 58.8～256μm,the mean size was 148.46 μm, drug content was 51.16%(w/w).The dissolution profiles of the CDDP-AMS followed Higuchi kinetics. In rabbits the distribution and elimination half times of platinum were prulonged 3. 36 times and 1.23 times vs injection group, respectively , after hepatic arterial chemoembolization with CDDP-AMS. The highest serum concentration of platinum is 30 percent of that of the injection grou The platinum concentration was increased in liver(P<0.01)and decreased in kidney(P<0.05) vs that of injection group.