THE EFFECT OF DIMETHYLTRILOBINE IODIDE ON EXPERIMENTAL ARRHYTHMIA AND ITS ELECTROPHYSIOLOGICAL ACTION ON MYOCARDIUM

In anaesthetized rats the onset of arrhythmia induced by aconitine was shown to be delayed by iv injection of dimethyltrilobine iodide(DMT)1 mg/kg. In anaesthetized guinea pigs the onset of arrhythmia induced by ouabain could also be delayed by ip injection DMT 1.5 mg/kg. DMT 0.25 mg/kg injected ip was found to protect rabbits against chloroform-adrenaline induced arrhythmia. APD₅₀ of ventricular myocardial cells of guinea pigs in situ was shown to be prolonged by ip injection of DMT 1.5 mg/kg. In isolated rabbit atrial muscle the functional refractory period was found to be prolonged by DMT 3.0x 10^-6M.