Sesquiterpenoids from the whole plant of Sarcandra glabra

To study the sesquiterpenoid constituents in the whole plant of Sarcandra glabra, silical column chromatography, Sephadex LH-20, reverse phase ODS column chromatography and preparative HPLC were used to isolate 70% EtOH extract of Sarcandra glabra.  The structures were elucidated based on spectroscopic data (HR-ESI-MS, ¹H NMR, ¹³C NMR, HSQC, HMBC and NOESY).  Four sesquiterpenoids were obtained and identified as 4α-hydroxy-5αH-lindan-8 (9)-en-8, 12-olide (1), chloranthalactone E (2), 8β, 9α-dihydroxylindan- (5), 7 (1)-ieb-8α, 12-olide (3) and chloranoside A (4), respectively.  Compound 1 is a new sesquiterpene lacone.