A STUDY OF THE INCLUSION COMPLEX OF WB852 WITH β-CYCLODEXTRIN
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Abstract
The aim of this study was to increase the stability of WB852 in aqueous solution by inclusion complex formation with β-cyclodextrin (β-CD). The stability of WB852-β-CD in aqueous solution was determined. The hydrolysis rate of WB852852 alone. The solid inclusion compound of WB852 with β-CD in 1: 3 molar ratio was prepared by the freeze-drying method. The formation of an inclusion compound with β-CD in solid state was confirmed by X-ray diffractometry, IR spectroscopy and differential thermal analysis (DTA).
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