STUDIES ON THE INCLUSION COMPOUND OF DIOXANE WITH PHTIOBUZONE

Inclusion compounds are the specialized form of molecular compounds. The constituents are usually present in constant, but not necessarily stoichiometric proportions.Phtiobuzone, 2,2'-1-1-(1,3(2H) dioxo-1H-isoindol-2yl) ethyl 1,2-ethanediyldene bis-hydrazine carbothioamide is a new ophthalmic antiviral agent. During crystallization from dioxane, crystals may consist of dioxane. This compound was studied by a variety of conventional analytical methods including melting behavior, differential thermal analysis and chromatographic analysis. According to the results of these experiments, it may be considered as a complex of dioxane with phtiobuzone and also an inclusion compound. The ratio of the drug to dioxane in the inclusion compound was about 1 : 1.