Zhang Zhen, Yen Min , Lei Xnghan, . CHEMOTHERAPEUTIC STUDIES ON FILARIASIS——Ⅱ. THE SYNTHESIS OF 5-NITRO-IMIDAZOLE DERIVATIVESJ. Acta Pharmaceutica Sinica, 1981, 16(7): 548-553.
Citation:
Zhang Zhen, Yen Min , Lei Xnghan, . CHEMOTHERAPEUTIC STUDIES ON FILARIASIS——Ⅱ. THE SYNTHESIS OF 5-NITRO-IMIDAZOLE DERIVATIVESJ. Acta Pharmaceutica Sinica, 1981, 16(7): 548-553.
Zhang Zhen, Yen Min , Lei Xnghan, . CHEMOTHERAPEUTIC STUDIES ON FILARIASIS——Ⅱ. THE SYNTHESIS OF 5-NITRO-IMIDAZOLE DERIVATIVESJ. Acta Pharmaceutica Sinica, 1981, 16(7): 548-553.
Citation:
Zhang Zhen, Yen Min , Lei Xnghan, . CHEMOTHERAPEUTIC STUDIES ON FILARIASIS——Ⅱ. THE SYNTHESIS OF 5-NITRO-IMIDAZOLE DERIVATIVESJ. Acta Pharmaceutica Sinica, 1981, 16(7): 548-553.
CHEMOTHERAPEUTIC STUDIES ON FILARIASIS——Ⅱ. THE SYNTHESIS OF 5-NITRO-IMIDAZOLE DERIVATIVES
In searching for new oral filaricides forty-one compounds of nitro-imidazole have been synthesized. After screening with L. carinii, nine compounds were found to possess obvious microfilaricidal and/or macrofilaricidal effects. Among them compounds Ⅰ1 and Ⅰ2 were shown to be the most effective macrofilaricides.
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