STUDIES ON PREPARATION AND CHARACTERISTICS OF CISPLATIN CHITOSAN MICROSPHERES

In this paper, the preparation, drug content, size and size distribution, appea-rance and. morphology, release characteristics in vitro and degradation characteristics of cisplatinchitosan microspheres (CDDPDAC-MS) were studied. CDDPDACMS were prepared by emulsion-crosalink technique. The CDDP-DAC-MS was shown to have rough spherical surface under scanningelectron microscopy. The average diameter of the microspheres was 74. 80 μm and CDDP content was20. 83%±0. 36%. CDDP-DAC-MS swelled slightly in saline after 1 h. Within the test period , therelease of CDDP from CDDP-DAC-MS in saline solution could be described by first-order equation.The microspheres were sterilized by ⁶⁰Co radiation. After 28 d of hepatic artery embolization withCDDP-DAC-MS in dogs, pathological photomicrograph showed that CDDP-DAC-MS could still beobserved.